DNA Repair Drugs can help prevent a cell from dying. These drugs work by inhibiting the enzymes that produce DNA. The drugs will then kill cancer cells by disrupting the cells' DNA. These drugs have the potential to improve the quality of life for patients and increase the longevity of cancer. Although DNA damage is irreversible, reversing the effects of the anti-cancer drugs is a challenge. The process of repair can be stopped with the use of drugs. The process is a natural process, and many diseases have the ability to cause this damage. Various types of chemotherapy can also lead to a damaged DNA. However, it is important to note that some of these drugs can cause damage to the DNA. To avoid this type of cancer, it is vital to use a DNA repair drug.
The research results suggest that DNA repair drugs can improve a patient's health. The potential benefits of these drugs are huge. A study conducted by researchers at the Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London, involved 21 patients with advanced solid tumors and mutations in the ATM gene. The trial was designed to assess the safety of the drug, as well as its maximum tolerated dose. Moreover, the researchers reported that the drug was well tolerated by the patients and had a positive effect on those with hereditary breast cancer.
The DNA repair pathway is implicated in the resistance to drugs. The effectiveness of anti-cancer agents depends on the ability of cancer cells to repair DNA damage. There are a number of DNA repair drugs in the market, which target specific DNA repair proteins and pathways. The problem with earlier approaches was the lack of specificity. The recent advances in this area have proven to be more effective and efficient. In fact, a few of these new treatments have already been approved in clinical trials. In June 2020, researchers at Dana-Farber Cancer Institute, Massachusetts, conducted a clinical trial in which a drug with new approach on impending DNA repair showed promising results in combination therapy with chemotherapy in patients suffering from an ovarian cancer.
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