Liver Fibrosis Treatment Is a Combination of Biological Therapy with Micro-Nutrients and Medical Procedures

Liver Fibrosis (also known as fatty liver disease) is a disease that can be either chronic or acute. Acute liver disease happens suddenly, usually due to some type of trauma. Chronic liver disease, on the other hand, occurs over time, sometimes due to a reaction to certain medications or a mild genetic enzyme deficiency. In Germany, cirrhosis is often a consequence of fatty liver disease due to alcoholism or other causes.

Advanced liver fibrosis treatment is a combination of biological therapy with micro-nutrients and medical procedures. Clinical studies suggest that these treatments improve clinical outcomes, but there is no proof in this regard. This combination includes chemotherapy with carboplatin, bromocriptine, methotrexate, cisplatin, vincristine, vinblastine, gemcitabine, intravenous immunoglobulin, vitamin K, methotrexate, or combination treatment. Another advanced liver injury and treatment is called extracorporeal shock wave therapy (ESWT), a combination of pharmacological and non-pharmacological approaches. This approach combines ESWL, which is an ultrafast laser treatment, with pharmacological agents such as doxorubicin, trifluoperazine, and chlorhexidine. These drugs interfere with protein synthesis, induce asthmatic-like responses, and reduce protein accumulation within the blood vessels. The combination of these two drugs reduces the amount of protein produced by the liver and thus prevents or delays the progression of liver fibrosis. Micro-nutrients support the cellular repair process, stimulate cell proliferation, and increase the expression of important molecules like superoxide dismutase (SOD), an antioxidant enzyme superoxide dismutase (OR Rebel), and glutathione,that may be affected by oxidative stress. Cytokines released by inflammatory cells bind the SOD and OR Rebel to stop their activities and prevent their accumulation.

A radical new approach in liver fibrosis treatment is provided by fibrosis-activated cells (FACS). These cells, which are not part of the inflammatory immune system, but rather form a protective layer around injured tissues, cause oxidative stress, activating inflammatory response causing fibrosis. They bind with oxidized proteins and trigger a release of cytokines, which in turn regulates the inflammatory response. This provides a natural repair system for injured tissues without the use of drugs. Although there is currently no cure for chronic liver disease, patients can take advantage of the many advances in treating this progressive disease.