Cyromazine is a cyclopropyl derivative of melamine and a triazine insect growth regulator. It affects the nervous system in certain insects, such as mosquitoes and cockroaches, during their immature larval stage. The active ingredient is cyclopropyl melamine, which is available as an organic vapor at home and a topical treatment. Cyromazine is a synthetic, non-organic phosphorus insect growth regulator. It is soluble in water and methanol at a concentration of 1.1 mg/mL and is not a drug. Its mode of action is research-oriented and is not intended for therapeutic use. While cyromazine has low toxicity, it is not a safe insecticide for any animal.
In addition to being toxic to humans, cyromazine is also toxic to many beneficial organisms. It is quickly absorbed into the skin and excreted from the body. Although most of it is excreted through urine, it does not contaminate groundwater. This means that cyromazine is not good for the environment. However, it is safe to use in research situations.
Cyromazine is not a natural insecticide. It is found in various pesticides. Some of them are even toxic to birds. Aside from affecting the health of humans, cyromazine has a limited safety profile. Despite its high toxicity, it is relatively harmless to most beneficial organisms. It is a common pesticide and is widely available in some countries. In regions such as India, the increasing prevalence of agricultural lands has increased the usage of cyromazine. For instance, according to the Indian Agricultural Association (IAA), India's agricultural land is around 159.7 million hectares.
While cyromazine is effective for insecticides, it is also capable of inhibiting the development of resistance in many insects. A study conducted on albino Sprague-Dawley rats found that male and female rat livers contained 31.3 and 62.4 ppm of cyromazine, respectively. Furthermore, female Sprague-Dawley mice exhibited a 22.2 ppm melamine content and a mere 0.04% cyromazine concentration.
Studies on cyromazine's effect on insect growth have shown that it inhibits the development of larvae and pupae in sheep. This chemical is a non-organic phosphorus insecticide with low toxicity to humans. Its pharmacological activity is unknown. While it is a potent insecticide, it may also affect humans if they are sensitive to it.
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